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The most important prognostic factor for pseudomyxoma peritonei (PMP) is the completeness of cytoreduction or the ability to remove all visible tumour nodules during the cytoreductive surgery.

The completeness of cytoreduction (CCR) was assessed using the CCR Score. Index that quantifies the extent of residual disease at the end of the procedure is classified into 4 categories:

  • CCR0 (no macroscopic residual disease)
  • CCR1 (residual tumours less than 2.5 mm)
  • CCR2 (residual tumours between 2.5 mm and 2.5 cm)
  • CCR3 (residual tumours greater than 2.5 cm)
CC0 No disease
CC1 present -> 0.25cm
CC2 0.25cm -> 2.5cm
CC3 >2.5cm

Studies have shown that patients with a complete cytoreduction (CCR-0 or CCR-1) have better long-term survival rates compared to those with incomplete cytoreduction (CCR-2 or CCR-3).

The histologic grade and subtype of the tumour, along with the patient’s age and general state of health, are additional prognostic markers. The most important element in determining the long-term prognosis of PMP patients, however, continues to be the completeness of cytoreduction.

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References

Cytoreductive surgery and intraperitoneal chemotherapy for peritoneal carcinomatosis...

Jo MH, Suh JW, Yun JS, Namgung H, Park D-G. Cytoreductive surgery and intraperitoneal chemotherapy for peritoneal carcinomatosis of colorectal cancer: 2-year follow-up results at a single institution in Korea. Annals of Surgical Treatment and Research. 2016;91(4):157. doi:10.4174/astr.2016.91.4.157

Consensuses and controversies on Pseudomyxoma Peritonei:...

Lin Y-L, Xu D-Z, Li X-B, et al. Consensuses and controversies on Pseudomyxoma Peritonei: A review of the published consensus statements and Guidelines. Orphanet Journal of Rare Diseases. 2021;16(1). doi:10.1186/s13023-021-01723-6

Written by: the Pseudomyxoma Survivor editorial team

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