The most important prognostic factor for pseudomyxoma peritonei (PMP) is the completeness of cytoreduction or the ability to remove all visible tumour nodules during the cytoreductive surgery.
The completeness of cytoreduction (CCR) was assessed using the CCR Score. Index that quantifies the extent of residual disease at the end of the procedure is classified into 4 categories:
- CCR0 (no macroscopic residual disease)
- CCR1 (residual tumours less than 2.5 mm)
- CCR2 (residual tumours between 2.5 mm and 2.5 cm)
- CCR3 (residual tumours greater than 2.5 cm)
| CC0 | No disease | |
| CC1 | present -> 0.25cm |  |
| CC2 | 0.25cm -> 2.5cm |  |
| CC3 | >2.5cm |  |
Studies have shown that patients with a complete cytoreduction (CCR-0 or CCR-1) have better long-term survival rates compared to those with incomplete cytoreduction (CCR-2 or CCR-3).
The histologic grade and subtype of the tumour, along with the patient’s age and general state of health, are additional prognostic markers. The most important element in determining the long-term prognosis of PMP patients, however, continues to be the completeness of cytoreduction.
More FAQs
What is the PCI score?
Doctors use the PCI score to help guide treatment options for Pseudomyxoma Peritonei (PMP) and other cancers that affect the lining of the abdomen.
Tumour markers CEA, CA125 and CA19-9, what are they and what do they mean?
A tumour marker is a substance of the blood that appears at a higher level than expected in your blood, in your urine or in a sample of your tissue. They may be produced by the presence of cancerous cells or by perfectly healthy cells.
Is cancer of the appendix genetic?
A recent study in JAMA Oncology revealed that around 10% of individuals diagnosed with appendiceal cancer have an inherited genetic variant that increases their risk for cancer predisposition. This is the first study to identify inherited risk factors for this uncommon type of cancer.
References
Cytoreductive surgery and intraperitoneal chemotherapy for peritoneal carcinomatosis...
Jo MH, Suh JW, Yun JS, Namgung H, Park D-G. Cytoreductive surgery and intraperitoneal chemotherapy for peritoneal carcinomatosis of colorectal cancer: 2-year follow-up results at a single institution in Korea. Annals of Surgical Treatment and Research. 2016;91(4):157. doi:10.4174/astr.2016.91.4.157
Consensuses and controversies on Pseudomyxoma Peritonei:...
Lin Y-L, Xu D-Z, Li X-B, et al. Consensuses and controversies on Pseudomyxoma Peritonei: A review of the published consensus statements and Guidelines. Orphanet Journal of Rare Diseases. 2021;16(1). doi:10.1186/s13023-021-01723-6
Written by: the Pseudomyxoma Survivor editorial team