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Goblet cell adenocarcinoma of the appendix is a rare type of cancer that arises from the goblet cells that are normally present in the lining of the appendix. The appendix is a small, finger-like pouch that is attached to the large intestine.

Goblet cell adenocarcinoma of the appendix is a subtype of appendiceal adenocarcinoma, which is itself a rare form of cancer. Goblet cell adenocarcinoma is characterized by the presence of tumour cells that secrete large amounts of mucin, a type of protein that gives mucus its slimy texture. This excess mucus production can cause the appendix to become enlarged and filled with mucus.

The exact cause of goblet cell adenocarcinoma of the appendix is not known, but it is believed to be related to genetic mutations that lead to the uncontrolled growth and division of the goblet cells in the appendix. Symptoms of goblet cell adenocarcinoma of the appendix may include abdominal pain, bloating, changes in bowel habits, and weight loss.

Diagnosis of goblet cell adenocarcinoma of the appendix typically involves a combination of imaging studies, such as CT or MRI scans, and a biopsy of the tumour tissue.

Because goblet cell adenocarcinoma of the appendix is a rare form of cancer, there is limited data on the prognosis and long-term outcomes of patients with this disease. However, early diagnosis and aggressive treatment may improve the chances of a favorable outcome.

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References

Goblet cell adenocarcinoma of the appendix: Diagnosis, prognosis and nomenclature

Wang HL (2022). Goblet cell adenocarcinoma of the appendix: Diagnosis, prognosis and nomenclature. Journal of Clinical and Translational Pathology. Published September 28, 2022. Retrieved on April 15, 2023, from doi: 10.14218/JCTP.2022.00018

Goblet cell adenocarcinoma

Lollie T, Wang HL. Goblet cell adenocarcinoma. PathologyOutlines.com website. Retrieved on april 15, 2023, from https://www.pathologyoutlines.com/topic/appendixgobletcellcarcinoid.html.

Written by the Pseudomyxoma Survivor editorial team.
Updated: June 2, 2023

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