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Goblet cell adenocarcinoma of the appendix is a rare type of cancer that arises from the goblet cells that are normally present in the lining of the appendix. The appendix is a small, finger-like pouch that is attached to the large intestine.

Goblet cell adenocarcinoma of the appendix is a subtype of appendiceal adenocarcinoma, which is itself a rare form of cancer. Goblet cell adenocarcinoma is characterized by the presence of tumour cells that secrete large amounts of mucin, a type of protein that gives mucus its slimy texture. This excess mucus production can cause the appendix to become enlarged and filled with mucus.

Once a doctor has determined that a person has goblet cell adenocarcinoma of the appendix, they will need to do some additional tests to figure out how far the cancer has spread. This usually involves doing a CT scan of the chest, abdomen, and pelvis to get a better look at the tumour. They may also do blood tests to look for certain proteins that can help detect cancer cells.

The treatment for goblet cell adenocarcinoma depends on how advanced the cancer is and what the cells look like under a microscope. Most doctors recommend surgery to remove the right side of the colon, which is where the appendix is located, to make sure they get all of the cancer cells. They may also check the lymph nodes near the area to see if the cancer has spread. In some cases, doctors may recommend removing the ovaries in post-menopausal women, as these tumours have a tendency to spread to the ovaries.

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Goblet cell adenocarcinoma of the appendix: Diagnosis, prognosis and nomenclature

Wang HL (2022). Goblet cell adenocarcinoma of the appendix: Diagnosis, prognosis and nomenclature. Journal of Clinical and Translational Pathology. Published September 28, 2022. Retrieved on April 15, 2023, from doi: 10.14218/JCTP.2022.00018

Goblet cell adenocarcinoma

Lollie T, Wang HL. Goblet cell adenocarcinoma. PathologyOutlines.com website. Retrieved on april 15, 2023, from https://www.pathologyoutlines.com/topic/appendixgobletcellcarcinoid.html.

Written by the Pseudomyxoma Survivor editorial team.
Updated: June 2, 2023

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