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Adenocarcinoma ex-goblet cell of the appendix is a type of cancer that originates from the cells that line the inside of the appendix. Specifically, it arises from cells called goblet cells, which produce mucus that helps to lubricate and protect the lining of the appendix. A study by Michelle D Reid et al. showed tumours occurred predominantly in females (74%).

In adenocarcinoma ex-goblet cells, the cancer cells no longer look like typical goblet cells but rather have undergone changes that make them appear more like other types of cancerous cells. This change in appearance is thought to be associated with a more aggressive form of cancer that can spread to other parts of the body.

Symptoms of adenocarcinoma ex-goblet cell of the appendix may include abdominal pain, bloating, changes in bowel habits, and weight loss. Diagnosis typically involves a combination of imaging studies, such as CT or MRI scans, and a biopsy of the tumour tissue.

The prognosis for this type of cancer can vary depending on the stage at which it is diagnosed, but early detection and aggressive treatment can improve the chances of a favourable outcome.


Adenocarcinoma ex-goblet cell carcinoidis a morphologically distinct entity...

Reid, M., Basturk, O., Shaib, W. et al. (2016). Adenocarcinoma ex-goblet cell carcinoid (appendiceal-type crypt cell adenocarcinoma) is a morphologically distinct entity with highly aggressive behavior and frequent association with peritoneal/intra-abdominal dissemination: an analysis of 77 cases. Mod Pathol 29, 1243–1253 (2016). doi:10.1038/modpathol.2016.105

Goblet cell carcinoid of the appendix – diagnostic challenges and treatment updates:

Gilmore, G., Jensen, K., Saligram, S. et al. (2018). Goblet cell carcinoid of the appendix – diagnostic challenges and treatment updates: a case report and review of the literature. J Med Case Reports 12, 275 (2018). doi:10.1186/s13256-018-1789-6

Written by: Pseudomyxoma Survivor editorial team
Updated: June 18, 2023

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