Although treating pseudomyxoma peritonei (PMP) can be difficult, most people living with PMP are typically treated with the goal of curing it. As the experience of specialists develops, there are a growing number of people with PMP who are experiencing many years with no evidence of disease¹ (NED) following cytoreductive surgery² and HIPEC³. The fact that the cancer is usually confined to a specific area (the abdomen) makes it more feasible to remove all of the cancer than certain other cancers. PMP typically does not spread throughout the entire body.
Written by the Pseudomyxoma Survivor editorial team
Updated March 30th, 2023
References
No evidence of disease
No evidence of disease means that tests are not detecting any cancer in the body.
HIPEC
Hyperthermic Intraperitoneal Chemotherapy
Heated chemotherapy, delivered directly into the abdomen, after complete cytoreduction. If the surgeons are able to remove the all the tumours, you may be given HIPEC.
Hyperthermic means that the chemotherapy solution used during the procedure is heated to a higher-than-normal temperature, typically around 41-43°C (105.8-109.4°F). This is usually Mitomycin C. This is put directly in your abdomen while you are in theatre. This elevated temperature is maintained throughout the duration of the procedure, usually around 90 minutes, to enhance the effectiveness of the chemotherapy drugs and to target cancer cells in the abdominal cavity. HIPEC will penetrate tumour nodules up to 2.5mm in size. The combination of chemotherapy drugs and hyperthermia can help to destroy cancer cells (increased cytotoxicity) while minimizing damage to healthy tissue.
Chemotherapy given into the abdomen during surgery is called intraoperative chemotherapy.
Complete cytoreduction
Complete cytoreduction is the complete surgical tumour removal. This is a long operation which takes about 10 hours to complete and includes:
- removal of the right hemicolon
- spleen
- gall bladder
- greater omentum and lesser omentum
- stripping of the peritoneum from the pelvis and diaphragms
- tripping of tumour from the surface of the liver
- removal of the uterus and ovaries in women
- removal of the rectum in some cases
This is also referred to as a full peritonectomy. The goal is to remove tumour nodules down to 2.5mm.
You might also want to read…
Will exercising cause pseudomyxoma peritonei (PMP) to spread?
Engaging in exercise is generally beneficial for overall health and well-being, even for individuals with pseudomyxoma peritonei (PMP). Exercise can help improve cardiovascular fitness, strengthen muscles, boost immune function, enhance mood, and promote a sense of...
Should I have CRS/HIPEC?
The decision to undergo cytoreductive surgery with HIPEC for pseudomyxoma peritonei (PMP) is a personal one and should be made in consultation with your medical team.
Why is HIPEC controversial?
Some doctors still view HIPEC (hyperthermic intraperitoneal chemotherapy) as a controversial procedure for multiple reasons.
I have PMP cancer. Not a lot of information available.
That’s interesting that you say that Roberta. When I was first diagnosed in 2003, the internet was in its infancy and information was really difficult to come across. I sometimes worry there is too much information out there now and it can be really confusing for those who have been diagnosed. One of the main reasons that Pseudomyxoma Survivor was set up to help patients navigate their way around. We hope you find our website helpful.