Facebook pixel

Although treating pseudomyxoma peritonei (PMP) can be difficult, most people living with PMP are typically treated with the goal of curing it. As the experience of specialists develops, there are a growing number of people with PMP who are experiencing many years with no evidence of disease¹ (NED) following cytoreductive surgery² and HIPEC³. The fact that the cancer is usually confined to a specific area (the abdomen) makes it more feasible to remove all of the cancer than certain other cancers. PMP typically does not spread throughout the entire body.

Written by the Pseudomyxoma Survivor editorial team
Updated March 30th, 2023


No evidence of disease

No evidence of disease means that tests are not detecting any cancer in the body.


Hyperthermic Intraperitoneal Chemotherapy

Heated chemotherapy, delivered directly into the abdomen, after complete cytoreduction.  If the surgeons are able to remove the all the tumours, you may be given HIPEC.

Hyperthermic means that the chemotherapy solution used during the procedure is heated to a higher-than-normal temperature, typically around 41-43°C (105.8-109.4°F). This is usually Mitomycin C. This is put directly in your abdomen while you are in theatre. This elevated temperature is maintained throughout the duration of the procedure, usually around 90 minutes, to enhance the effectiveness of the chemotherapy drugs and to target cancer cells in the abdominal cavity. HIPEC will penetrate tumour nodules up to 2.5mm in size. The combination of chemotherapy drugs and hyperthermia can help to destroy cancer cells (increased cytotoxicity) while minimizing damage to healthy tissue.

Chemotherapy given into the abdomen during surgery is called intraoperative chemotherapy.

Complete cytoreduction

Complete cytoreduction is the complete surgical tumour removal. This is a long operation which takes about 10 hours to complete and includes:

  • removal of the right hemicolon
  • spleen
  • gall bladder
  • greater omentum and lesser omentum
  • stripping of the peritoneum from the pelvis and diaphragms
  • tripping of tumour from the surface of the liver
  • removal of the uterus and ovaries in women
  • removal of the rectum in some cases

This is also referred to as a full peritonectomy.  The goal is to remove tumour nodules down to 2.5mm.

You might also want to read…

Home > Information about PMP > Frequently asked questions > Is pseudomyxoma peritonei curable?